Timothy Jenkins

AI-designed T-cell engagers for virus-driven Merkel cell carcinoma

This project de novo designs bispecific T-cell engagers that target viral peptide–MHC complexes presented on Merkel cell carcinoma, a rare and aggressive skin cancer. By combining generative protein design with rigorous functional validation, the work aims to create highly selective binders that redirect T cells specifically to tumor cells while minimizing off-target activity. The approach enables rapid in silico design followed by systematic in vitro and in vivo testing. The goal is to deliver a preclinical lead candidate with a clear path to IND-enabling studies and broader platform applicability.