Marie Meinsohn

Repurposing drugs for fertility preservation of prepubertal cancer patients.

Life expectancy for pediatric cancer patients is steadily improving. As more children survive cancer, there is a growing need to ensure their quality of life after chemotherapy. One major concern is that chemotherapy can harm prepurtal girls' ovarian reserve by both overactivating the pool of primordial follicles and triggering apoptosis in the granulosa cells of growing follicles.

The Anti-Müllerian hormone (AMH) is currently the only known hormone that can prevent the activation of primordial follicles. Our goal is to repurpose small molecules that we identified as AMH Receptor 2 (AMHR2) agonists to protect the ovaries from chemotherapy-induced damage. By doing so, we aim to prevent early menopause in pediatric cancer patients, preserving both their long-term hormonal health and their future fertility.